由多种因素引起的组织学图像的染色变化不仅是病理学家的视觉诊断，而且是细胞分割算法的挑战。为了消除颜色变化，已经提出了许多染色归一化方法。但是，大多数是为苏木精和曙红染色图像而设计的，并且在免疫组织化学染色图像上表现不佳。当前的细胞分割方法系统地将染色归一化作为预处理步骤，但是尚未定量研究颜色变化带来的影响。在本文中，我们制作了五组具有不同颜色的Neun染色图像。我们应用了一种深度学习的图像录制方法来在组织学图像组之间执行色彩转移。最后，我们改变了分割集的颜色，并量化了颜色变化对细胞分割的影响。结果证明了在后续分析之前必须进行颜色归一化的必要性。

细胞个体化对数字病理图像分析具有重要作用。深度学习被认为是用于实例分割任务的有效工具，包括细胞个性化。然而，深度学习模型的精度依赖于大规模的无偏见数据集和手动像素级注释，这是劳动密集型的。此外，大多数深度学习的应用已经开发用于加工肿瘤数据。为了克服这些挑战，i）我们建立了一个管道，以合成具有所提供的点注释的像素级标签;ii）我们测试了一项集体深度学习算法，以对神经数据进行细胞个体化。结果表明，所提出的方法成功地分离了物体级和像素水平的神经元细胞，平均检测精度为0.93。

A recent study has shown a phenomenon called neural collapse in that the within-class means of features and the classifier weight vectors converge to the vertices of a simplex equiangular tight frame at the terminal phase of training for classification. In this paper, we explore the corresponding structures of the last-layer feature centers and classifiers in semantic segmentation. Based on our empirical and theoretical analysis, we point out that semantic segmentation naturally brings contextual correlation and imbalanced distribution among classes, which breaks the equiangular and maximally separated structure of neural collapse for both feature centers and classifiers. However, such a symmetric structure is beneficial to discrimination for the minor classes. To preserve these advantages, we introduce a regularizer on feature centers to encourage the network to learn features closer to the appealing structure in imbalanced semantic segmentation. Experimental results show that our method can bring significant improvements on both 2D and 3D semantic segmentation benchmarks. Moreover, our method ranks 1st and sets a new record (+6.8% mIoU) on the ScanNet200 test leaderboard. Code will be available at https://github.com/dvlab-research/Imbalanced-Learning.

Weakly-supervised object localization aims to indicate the category as well as the scope of an object in an image given only the image-level labels. Most of the existing works are based on Class Activation Mapping (CAM) and endeavor to enlarge the discriminative area inside the activation map to perceive the whole object, yet ignore the co-occurrence confounder of the object and context (e.g., fish and water), which makes the model inspection hard to distinguish object boundaries. Besides, the use of CAM also brings a dilemma problem that the classification and localization always suffer from a performance gap and can not reach their highest accuracy simultaneously. In this paper, we propose a casual knowledge distillation method, dubbed KD-CI-CAM, to address these two under-explored issues in one go. More specifically, we tackle the co-occurrence context confounder problem via causal intervention (CI), which explores the causalities among image features, contexts, and categories to eliminate the biased object-context entanglement in the class activation maps. Based on the de-biased object feature, we additionally propose a multi-teacher causal distillation framework to balance the absorption of classification knowledge and localization knowledge during model training. Extensive experiments on several benchmarks demonstrate the effectiveness of KD-CI-CAM in learning clear object boundaries from confounding contexts and addressing the dilemma problem between classification and localization performance.

Witnessing the impressive achievements of pre-training techniques on large-scale data in the field of computer vision and natural language processing, we wonder whether this idea could be adapted in a grab-and-go spirit, and mitigate the sample inefficiency problem for visuomotor driving. Given the highly dynamic and variant nature of the input, the visuomotor driving task inherently lacks view and translation invariance, and the visual input contains massive irrelevant information for decision making, resulting in predominant pre-training approaches from general vision less suitable for the autonomous driving task. To this end, we propose PPGeo (Policy Pre-training via Geometric modeling), an intuitive and straightforward fully self-supervised framework curated for the policy pretraining in visuomotor driving. We aim at learning policy representations as a powerful abstraction by modeling 3D geometric scenes on large-scale unlabeled and uncalibrated YouTube driving videos. The proposed PPGeo is performed in two stages to support effective self-supervised training. In the first stage, the geometric modeling framework generates pose and depth predictions simultaneously, with two consecutive frames as input. In the second stage, the visual encoder learns driving policy representation by predicting the future ego-motion and optimizing with the photometric error based on current visual observation only. As such, the pre-trained visual encoder is equipped with rich driving policy related representations and thereby competent for multiple visuomotor driving tasks. Extensive experiments covering a wide span of challenging scenarios have demonstrated the superiority of our proposed approach, where improvements range from 2% to even over 100% with very limited data. Code and models will be available at https://github.com/OpenDriveLab/PPGeo.

In this work, we focus on instance-level open vocabulary segmentation, intending to expand a segmenter for instance-wise novel categories without mask annotations. We investigate a simple yet effective framework with the help of image captions, focusing on exploiting thousands of object nouns in captions to discover instances of novel classes. Rather than adopting pretrained caption models or using massive caption datasets with complex pipelines, we propose an end-to-end solution from two aspects: caption grounding and caption generation. In particular, we devise a joint Caption Grounding and Generation (CGG) framework based on a Mask Transformer baseline. The framework has a novel grounding loss that performs explicit and implicit multi-modal feature alignments. We further design a lightweight caption generation head to allow for additional caption supervision. We find that grounding and generation complement each other, significantly enhancing the segmentation performance for novel categories. We conduct extensive experiments on the COCO dataset with two settings: Open Vocabulary Instance Segmentation (OVIS) and Open Set Panoptic Segmentation (OSPS). The results demonstrate the superiority of our CGG framework over previous OVIS methods, achieving a large improvement of 6.8% mAP on novel classes without extra caption data. Our method also achieves over 15% PQ improvements for novel classes on the OSPS benchmark under various settings.

Nearest-Neighbor (NN) classification has been proven as a simple and effective approach for few-shot learning. The query data can be classified efficiently by finding the nearest support class based on features extracted by pretrained deep models. However, NN-based methods are sensitive to the data distribution and may produce false prediction if the samples in the support set happen to lie around the distribution boundary of different classes. To solve this issue, we present P3DC-Shot, an improved nearest-neighbor based few-shot classification method empowered by prior-driven data calibration. Inspired by the distribution calibration technique which utilizes the distribution or statistics of the base classes to calibrate the data for few-shot tasks, we propose a novel discrete data calibration operation which is more suitable for NN-based few-shot classification. Specifically, we treat the prototypes representing each base class as priors and calibrate each support data based on its similarity to different base prototypes. Then, we perform NN classification using these discretely calibrated support data. Results from extensive experiments on various datasets show our efficient non-learning based method can outperform or at least comparable to SOTA methods which need additional learning steps.

In this tutorial paper, we look into the evolution and prospect of network architecture and propose a novel conceptual architecture for the 6th generation (6G) networks. The proposed architecture has two key elements, i.e., holistic network virtualization and pervasive artificial intelligence (AI). The holistic network virtualization consists of network slicing and digital twin, from the aspects of service provision and service demand, respectively, to incorporate service-centric and user-centric networking. The pervasive network intelligence integrates AI into future networks from the perspectives of networking for AI and AI for networking, respectively. Building on holistic network virtualization and pervasive network intelligence, the proposed architecture can facilitate three types of interplay, i.e., the interplay between digital twin and network slicing paradigms, between model-driven and data-driven methods for network management, and between virtualization and AI, to maximize the flexibility, scalability, adaptivity, and intelligence for 6G networks. We also identify challenges and open issues related to the proposed architecture. By providing our vision, we aim to inspire further discussions and developments on the potential architecture of 6G.

In this paper, we investigate the joint device activity and data detection in massive machine-type communications (mMTC) with a one-phase non-coherent scheme, where data bits are embedded in the pilot sequences and the base station simultaneously detects active devices and their embedded data bits without explicit channel estimation. Due to the correlated sparsity pattern introduced by the non-coherent transmission scheme, the traditional approximate message passing (AMP) algorithm cannot achieve satisfactory performance. Therefore, we propose a deep learning (DL) modified AMP network (DL-mAMPnet) that enhances the detection performance by effectively exploiting the pilot activity correlation. The DL-mAMPnet is constructed by unfolding the AMP algorithm into a feedforward neural network, which combines the principled mathematical model of the AMP algorithm with the powerful learning capability, thereby benefiting from the advantages of both techniques. Trainable parameters are introduced in the DL-mAMPnet to approximate the correlated sparsity pattern and the large-scale fading coefficient. Moreover, a refinement module is designed to further advance the performance by utilizing the spatial feature caused by the correlated sparsity pattern. Simulation results demonstrate that the proposed DL-mAMPnet can significantly outperform traditional algorithms in terms of the symbol error rate performance.

The surrogate loss of variational autoencoders (VAEs) poses various challenges to their training, inducing the imbalance between task fitting and representation inference. To avert this, the existing strategies for VAEs focus on adjusting the tradeoff by introducing hyperparameters, deriving a tighter bound under some mild assumptions, or decomposing the loss components per certain neural settings. VAEs still suffer from uncertain tradeoff learning.We propose a novel evolutionary variational autoencoder (eVAE) building on the variational information bottleneck (VIB) theory and integrative evolutionary neural learning. eVAE integrates a variational genetic algorithm into VAE with variational evolutionary operators including variational mutation, crossover, and evolution. Its inner-outer-joint training mechanism synergistically and dynamically generates and updates the uncertain tradeoff learning in the evidence lower bound (ELBO) without additional constraints. Apart from learning a lossy compression and representation of data under the VIB assumption, eVAE presents an evolutionary paradigm to tune critical factors of VAEs and deep neural networks and addresses the premature convergence and random search problem by integrating evolutionary optimization into deep learning. Experiments show that eVAE addresses the KL-vanishing problem for text generation with low reconstruction loss, generates all disentangled factors with sharp images, and improves the image generation quality,respectively. eVAE achieves better reconstruction loss, disentanglement, and generation-inference balance than its competitors.